Tag Archive for: scaffolds

Professor Mats Brittberg

Volume 4 | Issue 1 | Jan – April 2019 | Page 23- 26


Author: Professor Mats Brittberg[1]

[1] Cartilage Research Unit, University of Gothenburg, Region Halland Orthopaedics, Kungsbacka Hospital, S-434 80 Kungsbacka Sweden.

Address of Correspondence
Professor- Mats Brittberg
Cartilage Research Unit, University of Gothenburg, Region Halland Orthopaedics, Kungsbacka Hospital, S-434 80 Kungsbacka Sweden.
Email: Mats.brittberg@telia.com


Abstract

Autologous chondrocyte implantation (ACI) has been used clinically since 1987. Most reports on ACI are on the first and second generation ACI with cells in suspension under a sutured membrane and performed with open surgery. Today’s 3rd and 4th generation ACI with cells seeded and grown in or on scaffolds prior to implantation opens up for transarthroscopic implantations. Transarthroscopic surgery reduces the morbidity for the patients and also fastens up the rehab process. In this paper, techniques used for scaffold-based ACI are presented.


References

1.Brittberg M, Lindahl A, Nilsson A et al.Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New England Journal of Medicine 1994; 331:889-895.
2.Brittberg M.Cartilage repair. On cartilaginous tissue engineering with the emphasis on chondrocyte transplantation. Thesis. University of Gothenburg.1996.
3.Brittberg M. Cell carriers as the next generation of cell therapy for cartilage repair: a review of the matrix-induced autologous chondrocyte implantation procedure.Am J Sports Med. 2010; Jun;38(6):1259-71.
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7.Brittberg M. Cartilage fragment implantation. . In Cartilage Surgery. An operative manual. Eds Brittberg M, Gersoff W. Elsevier Saunders Philadelphia,2011; 181-191.
8.Brittberg M, Concaro S. Transarthroscopic implantation of Hyalograft (Hyaff 11) with autologous chondrocytes. In Cartilage Surgery. An operative manual. Eds Brittberg M, Gersoff W. Elsevier Saunders Philadelphia,2011; 147-160.
9. Nehrer S, Dorotka R, Domayer S et al. Treatment of full-thickness chondral defects with hyalograft C in the knee: a prospective clinical case series with 2 to 7 years’ follow-up. Am J Sports Med. 2009; Nov;37 Suppl 1:81S-87S
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12.Della Villa S, Kon E, Filardo G et al. Does intensive rehabilitation permit early return to sport without compromising the clinical outcome after arthroscopic autologous chondrocyte implantation in highly competitive athletes? Am J Sports Med. 2010; Jan;38(1):68-77.


How to Cite this article: Brittberg M. Scaffold based autologous chondrocyte implantation: The surgical technique. Asian Journal Arthroscopy. Jan-April 2019;4(1):23-26 .


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