Tag Archive for: bone marrow

Katarzyna Herman, Vetri Kumar, Dawid Szwedowski, Luca Chierici, Alberto Gobbi

Volume 4 | Issue 1 | Jan – April 2019 | Page 34- 37


Author: Katarzyna Herman[1], Vetri Kumar[1], Dawid Szwedowski[1], Luca Chierici[1], Alberto Gobbi[1]

Orthopaedic Arthroscopic Surgery International (OASI) Bioresearch Foundation, Milan, Italy.

Address of Correspondence
Dr.Alberto Gobbi, MD
Orthopaedic Arthroscopic Surgery International (OASI) Bioresearch Foundation, Via G.A. Amadeo 24, 20133, Milan, Italy.
Email: gobbi@cartilagedoctor.it


Abstract

Articular cartilage is a highly specialized tissue with poor healing potential. Damage to the cartilage following an injury to the joint is prevalent which leads to osteoarthritis. More research is aimed towards tissue regeneration and prevention of degeneration. Efforts to repair and restore the hyaline like cartilage using two-stage procedures such as autologous chondrocyte implantation have led to the development of scaffolds. Bone marrow aspirate concentrate that contains multi potent stem cells which has the potential to differentiate into hyaline like cartilage along with the use of a scaffold is an effective, reliable and single-stage method of cartilage restoration


References

1.Hunter W. On the Structure and Diseases of Articulating Cartilage. Philos Trans RsocLond B Biol Sci 1743; 9:277.
2. Mankin HJ. The response of articular cartilage to mechanical injury. J Bone Joint Surg Am.1982;64(3):460-6.
3. Widuchowski W, Widuchowski J, Trzaska T(2007) Articular cartilage defects: study of 25,124 knee arthroscopies. Knee; 14:177-82
4. Flanigan DC, Harris JD, Trinh TQ, Siston RA, Brophy RH (2010) Prevalence of chondral defects in athletes’ knees: a systematic review. Med Sci Sports Exerc 42:1795–1801
5. Johnson DL, Urban WP Jr, Caborn DN et al (1998) Articular cartilage changes seen with magnetic resonance imaging-detected bone bruises associated with acute anterior cruciate ligament rupture. Am J Sports Med 26:409–414
6. Lohmander LS, Roos H, Dahlberg L et al (1994) Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus. J Orthop Res 12:21–28
7. Mandelbaum BR, Browne JE, Fu F et al (1998) Articular carti-lage lesions of the knee. Am J Sports Med 26:853–861
8. Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis Rheum. 2009 Dec;60(12):3546-53.
9. Takeda H, Nakagawa T, Nakamura K, Engebretsen L. Prevention and management of knee osteoarthritis and knee cartilage injury in sports. Br J Sports Med. 2011 Apr;45(4):304-9. Epub 2011 Feb 25.
10. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with Hyalograft(R) C: 3-year clinical results. Clin OrthopRelat Res 2005;435:96-105.
11. Gobbi A, Kon E, Berruto M, et al. Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation: Results at 5 years’ follow-up. Am J Sports Med 2009;37: 1083-1092
12. Ando W, Tateishi K, Katakai D, et al. In vitro generation of a scaffold-free tissue-engineered construct (TEC) derived from human synovial mesenchymal stem cells: biological and mechanical properties and further chondrogenic potential. Tissue Eng Part A. 2008;14(12): 2041-2049.
13. Caplan AI. Mesenchymal stem cells: cell-based reconstructive ther-apy in orthopedics. Tissue Eng. 2005;11(7-8):1198-1211.
14. Caplan AI. Mesenchymal stem cells: the past, the present, the future. Cartilage. 2010;1(1):6-9.
15. Dimarino AM, Caplan AI, Bonfield TL. Mesenchymal stem cells in tissue repair. Front Immunol. 2013;4:201.
16. Huselstein C, Li Y, He X. Mesenchymal stem cells for carti-lage engineering. Biomed Mater Eng. 2012;22:69-80.
17. Pasquinelli G, Orrico C, Foroni L, Bonafè F, Carboni M, Guarnieri C, et al. Mesenchymal stem cell interaction with a non-woven hyaluronan- based scaffold suitable for tissue repair. J Anat. 2008;213(5):520-30.
18. Lisignoli G, Cristino S, Piacentini A, Zini N, Noël D, Jorgensen C, et al. Chondrogenic differentiation of murine and human mesenchymal stromal cells in a hyaluronic acid scaffold: differences in gene expression and cell morphology. J Biomed Mater Res A. 2006;77(3):497-506.
19. Facchini A, Lisignoli G, Cristino S, Roseti L, De Franceschi L, Marconi E, et al. Human chondrocytes and mesenchymal stem cells grown onto engineered scaffold. Biorheology. 2006;43(3-4):471-80.
20. Nejadnik H, Hui JH, Feng Choong EP, Tai BC, Lee EH. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010 Jun; 38(6): 1110-6.
21. Gobbi A, Chaurasia S, Karnatzikos G, Nakamura N. Matrix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the Treatment of Large Patellofemoral Chondral Lesions: A Nonrandomized Prospective Trial. Cartilage. 2015 Apr;6(2):82-97.
22. Gobbi A, Karnatzikos G, Sankineani SR. One-step surgery with multipotent stem cells for the treatment of large full-thickness chondral defects of the knee. Am J Sports Med. 2014 Mar;42(3):64857.
23. Gobbi A et al. Biologic Arthroplasty for Full-thickness Cartilage Lesions of the Knee: Results at Three Years Follow-up (SS-56) Arthroscopy , Volume 29 , Issue 6 , e27
24. Gobbi A, Karnatzikos G, Scotti C, Mahajan V, Mazzucco L, Grigolo B. One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions: Results at 2-Year Follow-up. Cartilage.2011 Jul;2(3):286-99.
25. Gobbi A, Scotti C, Karnatzikos G, Mudhigere A, Castro M, Peretti GM. One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years. Knee Surgery, Sports Traumatology, Arthroscopy. 2017;25(8):2494-2501.
26. Whyte GP, Gobbi A, Sadlik B. Dry Arthroscopic Single-Stage Cartilage Repair of the Knee Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells. Arthroscopy Techniques. 2016;5(4):e913-e918.


How to Cite this article: Herman K, Kumar V, Szwedowski D, Chierici L, Gobbi A. HA-BMAC: The Surgical Technique, Pearls and Pitfalls . Asian Journal Arthroscopy. Jan-April 2019;4(1):34-37


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